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It should not be used immediately after a hot bath. Therefore, there is no need to continue to apply cream to the skin until it remains detectable on the surface. Older children should be supervised when applying the cream to ensure that a thorough treatment is administered. In view of the great variability in body area and skin types, precise dosage recommendations are not possible. In cases where the head, neck, scalp and ears are treated see belowthe dosage may be increased to ensure total body coverage.
Normally, up to one tube 30g. A few adults may need to use an additional tube for full body coverage but should not use more than 2 tubes 60g in total at each application. Apply the cream over the whole body but NOT the head and face. Pay particular attention to the areas between fingers and toes, under nails, wrists, armpits, external genitalia, breasts and buttocks. Avoid the area close to the eyes.
Pay particular attention to the areas between fingers and toes, under nails, wrists, armpits, palms of hands and soles of feet, external genitals and buttocks. Avoid the area around the mouth where the cream could be licked off and the area around the eyes. If there are no s of the original lesions healing or if new lesions have appeared, a second application can be made not less than 7 days after the first application.
In the event of inadvertent eye contamination, the affected area should be rinsed immediately with plenty of water or, if readily available, normal saline. In the case of hypersensitivity to chrysanthemums or other compositae, treatment should only be given if strictly indicated. In such cases treatment should be switched Cream the rabbit pregnant a chemically different agent. Healthcare professionals should be aware that if this product comes into contact with dressings, clothing and bedding, the Cream the rabbit pregnant can be easily ignited with a naked flame.
Patients should be warned of this risk and advised to keep away from fire when using this product. Therefore treatment must be given only under close medical supervision in this age group. Permethrin creams contains 0. Benzyl alcohol may cause allergic reactions. The likelihood of interactions between the two treatments leading to potentiated adverse reactions or reduced efficacy is, however small. The amount of permethrin absorbed systemically following a whole body application is extremely low. However, some permethrin may pass the placental barrier. The negative mutagenicity tests and the very low mammalian toxicity suggest that there is minimal risk to the foetus following treatment with permethrin.
It has been shown that very low concentrations of permethrin are excreted in milk following oral administration of permethrin in cattle.
It is not known whether permethrin is excreted in human breast milk. This occurs more frequently in patients with severe scabies and is usually mild and transient.
In patients treated for scabies, itching may persist for up to 4 weeks post-treatment. This is generally regarded as due to an allergic reaction to the dead mites under the skin and is not necessarily indicative of a treatment failure. If you get any side effects, talk to your doctor, pharmacist or nurse.
This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. By reporting side effects you can help provide more information on the safety of this medicine.
Treatment of hypersensitivity-type reactions should be symptomatic. The principal physiological action in susceptible parasites exposed to permethrin is induction of electrochemical abnormalities across the membranes of excitable cells, leading to sensory hyper-excitability, inco-ordination and prostration. It is assumed that the mode of action against arachnids mites is similar. Permethrin is rapidly metabolised in mammals by ester hydrolysis to inactive metabolites which are excreted principally in the urine.
The principal metabolites of permethrin are detectable in the urine within 7 hours of whole body application of the cream to healthy volunteers or scabies patients.
The highest levels of excretion are detectable within 48 hours but very low levels of metabolite are still detectable in the urine of some individuals 28 days after treatment. The overall pattern of excretion indicates a mean of approximately 0. In vitro and in vivo genetic toxicity studies were all negative, revealing no potential for permethrin to induce mutagenic changes. In repeated long-term bioassays for carcinogenic potential performed in rats, no evidence of oncogenicity was observed. Similar studies in mice have shown species specific increases in pulmonary adenomas, a common benign tumour of mice of high spontaneous background incidence.
It is considered that these findings do not indicate a ificant oncogenic potential for permethrin in humans.
Help us improve emc by letting us know which of the following best describes you. Toggle. Search emc: Enter medicine name or company Start typing to retrieve search suggestions. Continue typing to refine. Back to top Sandoz Limited contact details. Active ingredient permethrin. Legal Category P: Pharmacy. Last updated on emc: 24 Sep View changes Print. Show table of contents Hide table of contents 1. Name of the medicinal product 2. Qualitative and quantitative composition 3.
Pharmaceutical form 4. Clinical particulars 4. Pharmacological properties 5. Pharmaceutical particulars 6. Marketing authorisation holder 8. Marketing authorisation s 9.
Date of revision of the text. This information is intended for use by health professionals. Reapply the cream to the hands if they are washed within 8 hours of treatment. The whole body should be washed thoroughly hours after application. Children under 2 years should only be treated under medical supervision. Children 6 to 12 years Up to half a tube 15g. Children 1 to 5 years Up to a quarter of a tube 7. Children 2 months to 1 year Up to an eighth of a tube 3.
Excipients Permethrin creams contains 0. No interactions are known. There was no evidence of teratogenicity in reproduction studies in mice, rats and rabbits. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse.
Cetylstearyl alcohol White soft paraffin Macrogol cetostearyl ether Isopropylmyristate Benzyl alcohol Purified water. Aluminium tube with polypropylene cap. Contains 30g of cream. United Kingdom.
Company contact details Sandoz Limited. To bookmark a medicine you must up and log in. Up Log In Cancel. To a medicine you must up and log in.
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email: [email protected] - phone:(142) 567-7348 x 1597
The rabbit consultation and clinical techniques